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    woman holding her wrist What Is Arthritis?

    Arthritis is not one disease. Learn about the different types of arthritis, how they differ and why it’s important.

    microbes Inflammation and the Immune System

    Body-wide inflammation is at the root of most chronic diseases — and you may have more control over it than you think.

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    Woman holding shoulder Webinar: Touch Therapies for Pain Management

    Learn the evidence behind popular touch therapies for arthritis, including what to try and what to avoid, for how long and when.

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    Woman with upset stomach Microbiome, Gut Health & Arthritis

    Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. This episode was originally released on January 19, 2021.

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ACR News: Opening Session Focuses on COVID-19, 2020 Review

The annual meeting of the American College of Rheumatology (ACR) kicked off virtually Thursday , bringing together scientists, medical doctors, patients and others involved in the rheumatology field from around the globe. It will continue for five days with scientific sessions by some of the leading minds in the arena .

COVID-19 Treatments and Vaccines
The opening session included a lecture about inflammation and COVID-19 by Eric Rubin, MD , PhD, editor in chief of the New England Journal of Medicine and chair of Harvard U niversity’s T.H. Chan School of Public Health Department of Immunology and Infectious Diseases. Dr. Rubin discussed studies on the use of different anti-inflammatory drugs — many of them used to treat rheumatic diseases — as potential treatments for COVID-19. Results so far have been conflicting and nothing has emerged as a clear winner, but the studies have helped reveal that certain drugs may be more effective at certain stages of COVID-19 and at certain levels of disease severity .

Dr. Rubin also described the various types of vaccines and the significant challenges to developing safe, effective vaccines . The process typically takes years and large numbers of trial participants, and while a number of COVID-19 vaccines are in the works, he didn’t speculate as to when they would be safe and effective . He did say, however, that he believes many of the vaccine s will be inactivated, meaning they will be safe for immunosuppressed people, but it isn’t clear how effective they will be.

W ith other types of vaccines, studies also have found that vaccinated people don’t have the same decline in immunity over time compared with those who achieve immunity from contracting the disease. He expects the same to be true with a future COVID-19 vaccine.

2020 Review
Another highlight of the opening session was a look at 2020’s rheumatology newsmakers in c linic al science , presented by Jinoos Yazdhany , MD, professor of medicine and rheumatology at the University of California at San Francisco . Her top choices:

  1. Positive news for lupus. A study found the drug an i fr o l u mab ( which has not yet been approved by the Food and Drug Administration , FDA ) effective for moderate or severely active lupus , exclu d ing severe renal and central nervous system involvement . Another found tha t belimuma b may be a good option for lupus nephritis. W h at ’s more, Dr. Yazdhany says, anif r olumab appears to be effective for skin lesions , and trial participants taking it were able to reduce their gluco co rtic oid (steroid) doses.

  2. Better information on dosing and safety of glucocorticoids . Several studies showed that certain vasculitis and rheumatoid arthritis (RA) patients can safely taper their steroid dose (with guidance from their doctor) . In addition, even low doses of these steroids in some RA patients may increase the risk of hospitalization infection.

  3. More evidence about tapering drugs . While remission remains a goal for many patients and physicians, one study this year found that reducing the dose of an anti-tumor necrosis factor (TNF) biologic did not increase flares in participants with early axial spondylitis . And rituximab reduces vasculitis flares in some people over the long-term.

  4. More information about drug safety. A very large recent study found l ong-term (five years or more) use of bisphosph o nates , used to treat osteoporosis, increases the risk of unusual fractures of the femur (although still rare) . Stopping the drug dramatically drops the risk. However, fractures were found to occur more often in women of Asian descent. The upshot, says Dr. Yazdhany : Drug holidays should be recommended for all patients taking these drugs, especially for Asian American women. From a study of m ethotrexate in people with cardiovascular disease, Dr. Yazdhany extrapolated several side effects , including a “n ew safety s i gnal regarding s kin cancer .” In a l arge study of c olch ic ine ( commonly used to treat gout ) in patients with chronic coronary disease , “ 10% had to drop out , mostly for GI side effects ,” she says . “ Only 9 ou t of 10 patients could tolerate colchicine. ” However, it did appear to r educe heart attacks and stroke .

  5. New drugs for spondyloarthr itis ( SpA ) . Studies have found d rugs that use different pathways, or mechanisms, are effective for these conditions , providing more options for patients. Guselkumab , an interleukin-23 (IL-23) inhibitor, was effective for psoriatic arthritis patients who had not had adequate response to other therapies. And a new Janus kinase (JAK) inhibitor is showing promise for axial- SpA , which could give those patients a pill option.

  6. Rheumatology drugs as potential COVID-19 treatments. Dexamethasone reduced mortality in patients on ventilators , but had no benefit for patients who were not ventilated and “maybe a hint of harm” for those not receiving oxygen . Lots of studies have been done on h ydroxychloroquine in COVID-19 patients as a preventative , Dr. Yazdhany says, and “ e very single one of them was categorically negative , demonstrating that this drug has no role for the treatment of COVID-19.” The studies also found that even in high doses, hydroxychloroquine rarely leads to cardiac death . Other drugs also are being investigated, but more information is needed about how each affects which group of patients , because there’s a lot of variability, she says. The only drug shown to reduce mortality so far is dexamethasone , and that’s only in certain patients . Referring to a U.K. study of numerous therapies for hospitalized patients, she says, “I think this trial beautifully demonstrates that COVID-19 is not just one disease and that immunosuppressant medications might have a greater role in the later, hyper-inflammatory phases of the disease.” — JILL TYRER


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The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

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Live Yes! INSIGHTS


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community.

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families.

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.

Trailblazer

Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000

Visionary

Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.

Pioneer

Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.

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Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.

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Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.

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Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.

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