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  • About Arthritis
    Common Topics
    woman holding her wrist What Is Arthritis?

    Arthritis is not one disease. Learn about the different types of arthritis, how they differ and why it’s important.

    microbes Inflammation and the Immune System

    Body-wide inflammation is at the root of most chronic diseases — and you may have more control over it than you think.

    Patient talking with nurse Newly Diagnosed With Arthritis

    A new arthritis diagnosis can be overwhelming. These tips can help.

    • Understanding Arthritis
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    Woman holding shoulder Webinar: Touch Therapies for Pain Management

    Learn the evidence behind popular touch therapies for arthritis, including what to try and what to avoid, for how long and when.

    Managing Arthritis Care Costs

    Learn the basics about health care costs and financial tools available to you.

    Man with head in hands on bed Webinar: Arthritis Fatigue Causes and Solutions

    Learn the various causes of arthritis-related fatigue and strategies to combat weariness.

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    Woman with upset stomach Microbiome, Gut Health & Arthritis

    Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. This episode was originally released on January 19, 2021.

    man exercising Stairs Workout Demo

    Strengthen your leg muscles and improve your stability to make going up and down stairs safer and easier.

    woman consoling another Arthritis and Mental Health

    Learn about the connection between arthritis, depression and anxiety and how these conditions can make your arthritis worse.

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    2023 JA Family Summit

    Learn about the National Juvenile Arthritis Conference, a place for families to connect, share and learn.

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    The Arthritis Foundation’s JA camp programs give kids with arthritis and related childhood rheumatic diseases the chance to make lasting memories.

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    Transforming Clinical Interactions

    The Live Yes! Arthritis community connects patients with others online and in-person for support and education, and encourages patients to play an active role in their health care.

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    The Arthritis Foundation recently launched an initiative to build stronger relationships and increase recognition of our most engaged practices.

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    The Osteoarthritis Clinical Studies Forum Series features OA thought leaders from across the globe discussing the future of how the disease can be treated to improve patient outcomes.

    man bandaging boy's knee Conquering Childhood Arthritis

    The Arthritis Foundation is mobilizing patients and their families to engage in studies comparing the effectiveness of treatments for juvenile arthritis and funding research for more options.

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    Take action today - use the resources here to learn who your elected officials are, what opportunities we have to advocate from the comfort of your own home, federal and state legislation, and more!

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    Share your experience in a 10-minute assessment to be among those changing the future of arthritis.

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    You may have arthritis, but it doesn't have you. The Arthritis Foundation’s one-of-a-kind podcast. Hosted by patients, for patients.

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Researchers on the Path to a Cure – Spotlight on Dr. Caroline Jefferies

Lupus is a chronic, autoimmune disease and affects a wide part of the body, including the joints, kidneys, skin, blood, brain and other organs. One of our six Delivering on Discovery projects focuses on Lupus and lung disease. “Lupus is a complex disease. It affects many organs. The number of lupus patients with lung inflammation is probably underestimated. Yet it negatively impacts the quality of life in these patients,” explained Dr. Caroline Jefferies. “And while we have a basic understanding about how lupus affects various organs, we need to better understand how it affects the lungs to better manage and treat it.”

Dr. Jefferies is focusing on the lungs with her 3-year Arthritis Foundation-funded project, “ Inflammatory neutrophils in lupus lung disease -  novel cellular target ”.



Neutrophils are a type of white blood cell found in the immune system. They contain granules with enzymes that are released during infections and allergic reactions. During an immune response, neutrophils release some of their DNA in the form of neutrophil extracellular traps (NETs), which allow them to kill pathogens and minimize damage to cells.

When neutrophils are inappropriately activated, NETs drive inflammation and can contribute to tissue damage. Recently, NETs have been shown to be strongly involved in lupus heart and kidney disease. In terms of lung disease, NETs have been identified as playing a role in cystic fibrosis, as well as acute lung injury and infection patients.

Another factor the team is looking into is endoplasmic reticulum (ER) stress. The ER is a part of the cell that is involved in the construction of protein molecules and the transport of newly made proteins to other parts of the cell. ER stress can lead to the release of inflammatory molecules (cytokines) that attract cells to the damaged area and cause lung tissue structure to be changed. Dr. Jefferies is investigating whether ER stress can drive neutrophil activation and in this may drive autoimmune lung disease.

Dr. Jefferies and her team are trying to more fully understand the role of neutrophils and ER stress in lung injury caused by the immune system - first using mice, and in later stages of this study using human cell cultures. The team has been working on this project since April and expect to see results from the early mouse studies in early 2018.

Not long after coming to the U.S. from Dublin, Ireland in 2015, Dr. Jefferies and her team applied for the foundation’s Delivering on Discovery grant . She feels that the Arthritis Foundation’s mission and her personal goals are closely aligned. She is doing research that focuses on translation of research – creating a cure for patients. “When you have an autoimmune disease like lupus, your immune system constantly attacks your body, making it feel like you are always fighting a virus. But it’s not,” explained Dr. Jefferies. “We’re trying to figure out how to reset the immune system so that it stops attacking itself. This research will have applications to many autoimmune diseases, including many forms of arthritis – not just lupus.”

Dr. Jefferies is an associate professor/researcher with the Cedars-Sinai Medical Center Division of Rheumatology in Los Angeles, CA.

Related Resources:



  • Researchers on the Path to a Cure - Spotlight on Dr. Edward Doherty

  • Researchers on the Path to a Cure - Spotlight on Dr. Jordan Orange

  • Researchers on the Path to a Cure – Spotlight on Dr. Nora Singer

  • Researchers on the Path to a Cure – Spotlight on Dr. Richard F. Loeser, Jr

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The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

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Live Yes! INSIGHTS


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community.

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families.

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.

Trailblazer

Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000

Visionary

Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.

Pioneer

Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.

Pacesetter

Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.

Signature

Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.

Supporting

Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.

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