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  • About Arthritis
    Common Topics
    woman holding her wrist What Is Arthritis?

    Arthritis is not one disease. Learn about the different types of arthritis, how they differ and why it’s important.

    microbes Inflammation and the Immune System

    Body-wide inflammation is at the root of most chronic diseases — and you may have more control over it than you think.

    Patient talking with nurse Newly Diagnosed With Arthritis

    A new arthritis diagnosis can be overwhelming. These tips can help.

    • Understanding Arthritis
    • Arthritis Types
    • More About Arthritis
    • Where it Hurts
    • Related Conditions
  • Treatments
    Common Topics
    Woman holding shoulder Webinar: Touch Therapies for Pain Management

    Learn the evidence behind popular touch therapies for arthritis, including what to try and what to avoid, for how long and when.

    Managing Arthritis Care Costs

    Learn the basics about health care costs and financial tools available to you.

    Man with head in hands on bed Webinar: Arthritis Fatigue Causes and Solutions

    Learn the various causes of arthritis-related fatigue and strategies to combat weariness.

    • Treatment Plan
    • Drug Guide
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    Common Topics
    Woman with upset stomach Microbiome, Gut Health & Arthritis

    Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. This episode was originally released on January 19, 2021.

    man exercising Stairs Workout Demo

    Strengthen your leg muscles and improve your stability to make going up and down stairs safer and easier.

    woman consoling another Arthritis and Mental Health

    Learn about the connection between arthritis, depression and anxiety and how these conditions can make your arthritis worse.

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    2023 JA Family Summit

    Learn about the National Juvenile Arthritis Conference, a place for families to connect, share and learn.

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    The Arthritis Foundation’s JA camp programs give kids with arthritis and related childhood rheumatic diseases the chance to make lasting memories.

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    Transforming Clinical Interactions

    The Live Yes! Arthritis community connects patients with others online and in-person for support and education, and encourages patients to play an active role in their health care.

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    The Arthritis Foundation recently launched an initiative to build stronger relationships and increase recognition of our most engaged practices.

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    See how we're aiming to address the growing shortage of arthritis specialists, especially in under-served parts of the country.

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    OACS Forum Series

    The Osteoarthritis Clinical Studies Forum Series features OA thought leaders from across the globe discussing the future of how the disease can be treated to improve patient outcomes.

    man bandaging boy's knee Conquering Childhood Arthritis

    The Arthritis Foundation is mobilizing patients and their families to engage in studies comparing the effectiveness of treatments for juvenile arthritis and funding research for more options.

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    Capital hill Action Center

    Take action today - use the resources here to learn who your elected officials are, what opportunities we have to advocate from the comfort of your own home, federal and state legislation, and more!

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    Share your experience in a 10-minute assessment to be among those changing the future of arthritis.

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    You may have arthritis, but it doesn't have you. The Arthritis Foundation’s one-of-a-kind podcast. Hosted by patients, for patients.

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Researchers on the Path to a Cure - Spotlight on Dr. Xiaojuan Li

Osteoarthritis (OA) affects over 30 million people and is the most common cause of disability in adults in the U.S. The Arthritis Foundation has set the goal of advancing OA treatments as one of its highest priorities, making it one of the Foundation’s four scientific initiatives. To do this, we have created the OA Center of Excellence (COE), where researchers from around the county can join the Clinical Trial Network to work together to accelerate the development of new OA therapies.

The OA COE is currently funding three Clinical Trial Network demonstration studies that may lead to better diagnosis and earlier treatments. Researchers from six different institutions will collaborate in various aspects of these cutting-edge studies. We will look at each of these studies in a series of blogs.



Dr. Xiaojuan Li is the principal investigator of the study “ Multi-site Multi-Vendor Cross-validation of Cartilage T1rho and T2 imaging ”. The team, made up investigators from four sites (the Cleveland Clinic Foundation [CCF] in Ohio, the University of California San Francisco, the University of Kentucky, and the University Hospital for Albert Einstein College of Medicine in New York) are working to quantify biomarker assessments in cartilage images obtained through magnetic resonance imaging (MRI) . The study will take about six months to complete.

MRI has the advantage over other imaging method in being able to view cartilage, in addition to muscles, tendons, and bones. Articular (joint) cartilage is very thin and made up of cells (chondrocytes), proteins, water, and other molecules that help it retain water and maintain its structure. Retaining water is critical for the cartilage to maintain joint health and protect bones.

The most common MRI images are collected from two types of scans: T1-weighted and T2-weighted scans. Generally, T1-weighted images look at only fat tissue, while T2-weighted images look at fat and water in the tissue (cartilage). These currently used techniques are limited to evaluate structural changes of cartilage (like cartilage thinning and fissuring).

Dr. Li and the investigative team are evaluating new techniques with T1rho and T2 imaging which can detect biochemical changes within the cartilage matrix before structural changes can be seen. These biochemical changes represent promising biomarkers that are more sensitive for detecting the very early stages of OA , and for evaluating cartilage changes after treatment (treatment response).

T1rho and T2 measures and test result interpretation can vary based on many factors. Things like the positioning of the patient, the temperature of the room where the images are taken, and many other factors can affect results. Test results can also vary from radiologist to radiologist, partially due to the differences in the equipment made by different manufacturers for these tests. The team will standardize procedures (like patient positioning, room temperature, etc.) and will compare the imaging results obtained from three different imaging manufacturers commonly used around the U.S. (Siemens, Philips, and GE). The team is interested in seeing how much difference there may be between test results obtained.

The team will use T1rho and T2 measures as imaging biomarkers. They plan to do scans of 5 subjects at each site. There will also be 2 or 3 traveling subjects who will be imaged at all four sites (to compare sites). The first human subject was recently enrolled and scanned at CCF. The team expects to complete scans of all human subjects by May 2018.

Each site will also have man-made “phantom” joints made from material similar to human cartilage. This will allow them to calibrate and standardize the imaging machines across sites. The phantoms also allow each site to take multiple images with a joint with known parameters, as often as needed.

Dr. Li and her team will attempt to quantify these imaging biomarkers to create algorithms to standardize the measures. Once this is done, the standard measures can become automated, making test result interpretations consistent.

Dr. Li works in the biomedical engineering department, and directs the program of advanced musculoskeletal imaging (PAMI) of the CCF in Ohio.

Related Resources:



  • Arthritis Foundation: Advancing Osteoarthritis Treatments

  • Researchers on the Path to a Cure - Spotlight on Dr. Caroline Jefferies

  • Researchers on the Path to a Cure - Spotlight on Dr. Edward Doherty

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The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

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Live Yes! INSIGHTS


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community.

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families.

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.

Trailblazer

Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000

Visionary

Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.

Pioneer

Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.

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Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.

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Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.

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Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.

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