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Do I Have Arthritis?
Think you may have arthritis? Learn about the four most common warning signs.
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Gout is an inflammatory type of arthritis that can come and go.
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  • About Arthritis
    Common Topics
    woman holding her wrist What Is Arthritis?

    Arthritis is not one disease. Learn about the different types of arthritis, how they differ and why it’s important.

    microbes Inflammation and the Immune System

    Body-wide inflammation is at the root of most chronic diseases — and you may have more control over it than you think.

    Patient talking with nurse Newly Diagnosed With Arthritis

    A new arthritis diagnosis can be overwhelming. These tips can help.

    • Understanding Arthritis
    • Arthritis Types
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    Common Topics
    Woman holding shoulder Webinar: Touch Therapies for Pain Management

    Learn the evidence behind popular touch therapies for arthritis, including what to try and what to avoid, for how long and when.

    Managing Arthritis Care Costs

    Learn the basics about health care costs and financial tools available to you.

    Man with head in hands on bed Webinar: Arthritis Fatigue Causes and Solutions

    Learn the various causes of arthritis-related fatigue and strategies to combat weariness.

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    Woman with upset stomach Microbiome, Gut Health & Arthritis

    Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. This episode was originally released on January 19, 2021.

    man exercising Stairs Workout Demo

    Strengthen your leg muscles and improve your stability to make going up and down stairs safer and easier.

    woman consoling another Arthritis and Mental Health

    Learn about the connection between arthritis, depression and anxiety and how these conditions can make your arthritis worse.

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    2023 JA Family Summit

    Learn about the National Juvenile Arthritis Conference, a place for families to connect, share and learn.

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    The Arthritis Foundation’s JA camp programs give kids with arthritis and related childhood rheumatic diseases the chance to make lasting memories.

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    Transforming Clinical Interactions

    The Live Yes! Arthritis community connects patients with others online and in-person for support and education, and encourages patients to play an active role in their health care.

    Partners 4 Patients with Arthritis

    The Arthritis Foundation recently launched an initiative to build stronger relationships and increase recognition of our most engaged practices.

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    See how we're aiming to address the growing shortage of arthritis specialists, especially in under-served parts of the country.

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    OACS Forum Series

    The Osteoarthritis Clinical Studies Forum Series features OA thought leaders from across the globe discussing the future of how the disease can be treated to improve patient outcomes.

    man bandaging boy's knee Conquering Childhood Arthritis

    The Arthritis Foundation is mobilizing patients and their families to engage in studies comparing the effectiveness of treatments for juvenile arthritis and funding research for more options.

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    Capital hill Action Center

    Take action today - use the resources here to learn who your elected officials are, what opportunities we have to advocate from the comfort of your own home, federal and state legislation, and more!

    LiveYes! Insights thumbnail Live Yes! INSIGHTS

    Share your experience in a 10-minute assessment to be among those changing the future of arthritis.

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    You may have arthritis, but it doesn't have you. The Arthritis Foundation’s one-of-a-kind podcast. Hosted by patients, for patients.

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Researchers on the Path to a Cure - Spotlight on Dr. Jose Scher

Dr. Jose U. Scher, a current Arthritis Foundation-funded investigator, has been looking at the relationship between bacteria and inflammatory diseases for more than 10 years. Dr. Scher’s current Arthritis Foundation funded project, “Pan-Microbiome in At-Risk Subjects and New-Onset Rheumatoid Arthritis (RA),” looks at the relationship of bacteria (or “microbiome” in the mouth, lungs, and intestines) and the development of RA .


“Different areas of the body have different populations of microbes,” Dr. Scher explained. “What is important is the diversity, or different types and numbers of bacteria. When we look at the bacteria found in the mouth, lungs, and gut of healthy individuals and compare them to those found in new RA patients who have not been treated yet, we see differences. The diversity of bacteria in each area changes in the RA patient. Certain bacteria may disappear and others may increase in numbers. In a healthy individual, there is a balance in the diversity of bacteria. It makes us question whether certain bacteria are triggering the body to produce an immune response.”

Dr. Scher began his work in immunology, looking at potential triggering factors for autoimmune diseases, specifically microbiomes and triggering effects. “We are asking: can you modify the microbiome in order to treat or prevent autoimmunity?” he explained. “Pharmaceutical companies are looking for the cocktail of microbes that can help patients. But what if it is not the microbes themselves, but the metabolites (chemicals) they produce that is important? Are some of the metabolites produced by certain bacteria beneficial? These are questions that need to be answered before we can come up with a safe and effective therapy.”

In a paper published in the November 2016 issue of BioMed Central Microbiome , Dr. Scher looked at the relationship in types and numbers of bacteria in the lungs and the possible development of RA. The study looked at lung fluids collected from untreated early-stage RA patients, healthy patients, and patients with lung sarcoidosis (an inflammatory disease that affects mostly the lungs). The study found that there were fewer types and amounts of bacteria found in the lungs of RA patients when compared to the lungs of healthy patients. The types and amounts of bacteria found in the lungs of the untreated early-stage RA patients were similar to those found in the sarcoidosis patients. The conclusion was that the bacteria in the lungs may drive the development of RA in some cases.

Dr. Scher also presented the results from a different study looking at the relationship between methotrexate, bacteria, and RA at the November 2016 ACR annual meeting. The results of that study showed that some bacteria respond more positively to methotrexate than others. “This offers the potential for a personalized medicine approach,” Dr. Scher explained. “By testing which bacteria are present in the gut, we can predict who will respond best to methotrexate. This could save some patients a lot of time and money if they knew they would be less likely to respond to that type of treatment.”

While Dr. Scher is optimistic about the future of microbiome research, he also cautions people. “There are a lot of steps between the development of a concept, research, and finding a true therapy. It takes time. I am thankful to the Arthritis Foundation for allowing us to be their partners in doing this important research.”

Dr. Scher is a rheumatologist at New York University Langone Medical Center.
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Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift.

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Volunteer Opportunities

The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

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Live Yes! INSIGHTS


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community.

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families.

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Partner


Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.

Trailblazer

Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000

Visionary

Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.

Pioneer

Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.

Pacesetter

Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.

Signature

Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.

Supporting

Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.

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