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  • About Arthritis
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    woman holding her wrist What Is Arthritis?

    Arthritis is not one disease. Learn about the different types of arthritis, how they differ and why it’s important.

    microbes Inflammation and the Immune System

    Body-wide inflammation is at the root of most chronic diseases — and you may have more control over it than you think.

    Patient talking with nurse Newly Diagnosed With Arthritis

    A new arthritis diagnosis can be overwhelming. These tips can help.

    • Understanding Arthritis
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    Woman holding shoulder Webinar: Touch Therapies for Pain Management

    Learn the evidence behind popular touch therapies for arthritis, including what to try and what to avoid, for how long and when.

    Managing Arthritis Care Costs

    Learn the basics about health care costs and financial tools available to you.

    Man with head in hands on bed Webinar: Arthritis Fatigue Causes and Solutions

    Learn the various causes of arthritis-related fatigue and strategies to combat weariness.

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    Woman with upset stomach Microbiome, Gut Health & Arthritis

    Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. This episode was originally released on January 19, 2021.

    man exercising Stairs Workout Demo

    Strengthen your leg muscles and improve your stability to make going up and down stairs safer and easier.

    woman consoling another Arthritis and Mental Health

    Learn about the connection between arthritis, depression and anxiety and how these conditions can make your arthritis worse.

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    2023 JA Family Summit

    Learn about the National Juvenile Arthritis Conference, a place for families to connect, share and learn.

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    The Arthritis Foundation’s JA camp programs give kids with arthritis and related childhood rheumatic diseases the chance to make lasting memories.

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    Transforming Clinical Interactions

    The Live Yes! Arthritis community connects patients with others online and in-person for support and education, and encourages patients to play an active role in their health care.

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    The Arthritis Foundation recently launched an initiative to build stronger relationships and increase recognition of our most engaged practices.

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    See how we're aiming to address the growing shortage of arthritis specialists, especially in under-served parts of the country.

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    OACS Forum Series

    The Osteoarthritis Clinical Studies Forum Series features OA thought leaders from across the globe discussing the future of how the disease can be treated to improve patient outcomes.

    man bandaging boy's knee Conquering Childhood Arthritis

    The Arthritis Foundation is mobilizing patients and their families to engage in studies comparing the effectiveness of treatments for juvenile arthritis and funding research for more options.

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    Take action today - use the resources here to learn who your elected officials are, what opportunities we have to advocate from the comfort of your own home, federal and state legislation, and more!

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    Share your experience in a 10-minute assessment to be among those changing the future of arthritis.

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    You may have arthritis, but it doesn't have you. The Arthritis Foundation’s one-of-a-kind podcast. Hosted by patients, for patients.

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Causes of Fatigue in Arthritis

Inflammation, pain, inactivity and lifestyle factors can cause extreme tiredness when living with arthritis.

Everyone gets worn out from time to time. But exhaustion that disrupts your daily life and doesn’t get better after a good night’s sleep has its own medical term: fatigue. Fatigue significantly affects the quality of life for people with many forms of arthritis-related diseases, including rheumatoid arthritis , psoriatic arthritis , spondyloarthritis , lupus , fibromyalgia and osteoarthritis . Your lack of energy may be caused by your inflammatory disease and other health conditions you have, as well as medications side effects and lifestyle habits.

Disease Activity and Sleep

Fatigue and sleep problems go hand-in-hand for many people with arthritis. The main culprits are the inflammatory disease process and the accompanying chronic pain.

  • Inflammation. If you have an autoimmune disease, your immune system attacks your body and inflammation is the result. The body undergoes stress as it tries to cope with the release of inflammatory cytokines (proteins) in the blood. That can cause fatigue, especially when disease activity is high or low-grade inflammation remains for a long time.
  • Chronic Pain. The pain-fatigue connection can be a vicious circle. Dealing with arthritis pain for months at a time over many years can wear you down. It can affect your sleep habits, which adds to your exhaustion. Being fatigued, in turn, can worsen pain and make it more difficult to manage.

Other Sources of Fatigue

Your fatigue is not always directly related to your arthritis disease activity, inflammation or pain. In fact, according to a 2017 study published in Current Rheumatology Reports, your fatigue level probably has more to do with other contributing factors, including obesity, physical inactivity, sleep disturbance and depression. Several of them may work together to cause your extreme tiredness, but identifying and treating even one of these factors can provide relief.

  • Medication side effects. Several medications , including some you may take for arthritis, can cause drowsiness or fatigue. Common culprits include certain antidepressants; blood pressure medication; narcotic pain relievers; some prescription nonsteroidal anti-inflammatories (NSAIDs); and certain disease-modifying antirheumatic drugs (DMARDs), such as azathioprine and methotrexate. Corticosteroids may cause daytime tiredness by keeping you awake at night.
  • Inactivity. The more you lie around, the more exhausted you feel. Unused muscles — including the heart muscle — can weaken, and you get tired more easily. A 2017 study published in Scandinavian Journal of Medicine & Science in Sports found that people with fibromyalgia who spent less time sitting and more time doing light physical activity had lower levels of fatigue and pain than those who were inactive.
  • Anemia. Fatigue in arthritis may be caused by anemia — a shortage of red blood cells. Without enough red blood cells, your muscles get tired fast, resulting in fatigue. Up to two-thirds of people with arthritis have a condition called anemia of chronic disease, which occurs when inflammatory chemicals interfere with the body’s production of red blood cells.
  • Lack of Sleep. Fatigue may be triggered by insomnia and unrefreshing sleep . Getting into a comfortable position or staying asleep can be a challenge when joints are swollen and sore. Tossing and turning in bed or waking up repeatedly is a reality for some people with arthritis pain. Sleep apnea, a condition in which breathing is interrupted during sleep, can also contribute to poor sleep.
  • Obesity. Being very overweight can cause sleep apnea or other sleep problems, resulting in daytime fatigue. But studies show that obese people with no sleep disturbance are also fatigued. Lack of exercise, using extra energy to move more bodyweight and metabolic changes that often accompany obesity also contribute to fatigue.
  • Poor nutrition. Not getting adequate and healthy food and fluids can be causes of fatigue that fly under the radar. Your body needs plenty of water, vitamins and minerals to operate efficiently. If you love junk food and don’t drink enough water or other healthy beverages, your fatigue could be from dehydration and vitamin deficiency.
  • Depression. Arthritis pain can take you away from doing the things you enjoy, so it’s no surprise depression often goes hand-in-hand with the disease. Research shows depression may also result from changes in your hormones and brain caused by dealing with the stress of a chronic illness.
  • Loss of muscle mass. When you lose muscle tissue, the remaining muscles have to bear the burden of moving your body. Loss of muscle can come from inactivity. But some people with severe inflammatory arthritis have a condition called cachexia, in which muscle mass decreases and fatigue increases.
  • Other medical conditions. Having arthritis increases your risk of other health problems, such as heart disease, lung disease, diabetes and inflammatory bowel disease — all of which can be associated with fatigue. Other conditions not specifically related to arthritis may also lead to fatigue. These include infection, liver or kidney disease, thyroid disease and chronic fatigue syndrome.

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Volunteer Opportunities

The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

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Live Yes! INSIGHTS


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community.

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families.

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.

Trailblazer

Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000

Visionary

Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.

Pioneer

Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.

Pacesetter

Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.

Signature

Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.

Supporting

Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.

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